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Invitrogen
GRB2 Monoclonal Antibody (2GB04 (C1.4))
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-12165
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat,
Xenopus
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2GB04 (C1.4)
抗原
Purified recombinant human Grb2 protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-12165 targets Grb2 in IF and IHC (P) applications and shows reactivity with Bovine, Human, mouse, Rat, and Xenopus laevis samples.
The MA5-12165 immunogen is purified recombinant human Grb2 protein.
靶标信息
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2-Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: abundant SRC homology; adapter protein GRB2; adapter protein GRB2-A; adaptor protein; ASH protein; epidermal growth factor receptor-binding protein GRB2; epididymis secretory sperm binding protein; GRB2; growth factor receptor-bound protein 2; growth factor receptor-bound protein 2-like; growth factor receptor-bound protein 3; HT027; OTTHUMP00000166097; OTTHUMP00000166098; protein Ash; SH2/SH3 adapter GRB2; SH2/SH3 adapter GRB2-A; SH2/SH3 adaptor Grb2; unnamed protein product
基因别名: ASH; Ash-psi; EGFRBP-GRB2; grb2; grb2-a; grb2-b; Grb3-3; MST084; MSTP084; NCKAP2; XELAEV_18044055mg
UniProt ID: (Human) P62993, (Mouse) Q60631, (Rat) P62994, (Xenopus) P87379
Entrez Gene ID: (Human) 2885, (Bovine) 535298, (Mouse) 14784, (Rat) 81504, (Xenopus) 399458
phosphotyrosine binding
RNA binding
transmembrane receptor protein tyrosine kinase adaptor activity
guanyl-nucleotide exchange factor adaptor activity
epidermal growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
SH3 domain binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
protein binding, bridging
identical protein binding
insulin receptor substrate binding
ephrin receptor binding
enzyme binding
macromolecular complex binding
phosphoprotein binding
binding, bridging
signal transduction
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
Schwann cell development
actin cytoskeleton organization
cell differentiation
positive regulation of actin filament polymerization
T cell costimulation
receptor internalization
ERBB2-ERBB3 signaling pathway
T cell activation
natural killer cell mediated cytotoxicity
myelination
signal transduction in response to DNA damage
regulation of MAPK cascade
negative regulation of natural killer cell mediated cytotoxicity
insulin-like growth factor receptor signaling pathway
anatomical structure formation involved in morphogenesis
B cell receptor signaling pathway
branching involved in labyrinthine layer morphogenesis
cellular response to ionizing radiation
positive regulation of reactive oxygen species metabolic process
positive regulation of Rac protein signal transduction
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