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Proteintech
GRK5 Polyclonal Antibody
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产品信息
17032-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GRK5 Fusion Protein Ag10511 (186-590 aa encoded by BC064506)
偶联物
形式
Liquid
浓度
0.28 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: FRQYRVLGK GGFGEVCACQ VRATGKMYAC KRLEKKRIKK RKGESMALNE KQILEKVNSQ FVVNLAYAYE TKDALCLVLT IMNGGDLKFH IYNMGNPGFE EERALFYAAE ILCGLEDLHR ENTVYRDLKP ENILLDDYGH IRISDLGLAV KIPEGDLIRG RVGTVGYMAP EVLNNQRYGL SPDYWGLGCL IYEMIEGQSP FRGRKEKVKR EEVDRRVLET EEVYSHKFSE EAKSICKMLL TKDAKQRLGC QEEGAAEVKR HPFFRNMNFK RLEAGMLDPP FVPDPRAVYC KDVLDIEQFS TVKGVNLDHT DDDFYSKFST GSVSIPWQNE MIETECFKEL NVFGPNGTLP PDLNRNHPPE PPKKGLLQRL FKRQHQNNSK SSPSSKTSFN HHINSNHVSS NSTGSS (186-590 aa encoded by BC064506)
靶标信息
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha-CP4; FP2025; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; Poly(rC)-binding protein 4
基因别名: 1200003L19Rik; AlphaCP-4; GPRK5; GRK5; Pcbp4
UniProt ID: (Human) P34947, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) P57724
Entrez Gene ID: (Human) 2869, (Mouse) 14773, (Rat) 59075, (Mouse) 59092
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
protein kinase C binding
protein binding
ATP binding
phospholipid binding
beta-adrenergic receptor kinase activity
nucleotide binding
protein kinase activity
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
desensitization of G-protein coupled receptor protein signaling pathway
apoptotic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
response to drug
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
protein phosphorylation
signal transduction
phosphorylation
termination of G-protein coupled receptor signaling pathway
negative regulation of mRNA splicing, via spliceosome
