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Invitrogen
GRK5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79331
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human GRK5 (393-429aa KREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAK).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human Hela whole cell, human A549 whole cell, rat heart tissue, mouse heart tissue. IHC: rat cardiac muscle tissue, mouse lung tissue, human placenta tissue.
靶标信息
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-CP4; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; Poly(rC)-binding protein 4
基因别名: 1200003L19Rik; AlphaCP-4; GPRK5; GRK5; Pcbp4
UniProt ID: (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) P57724
Entrez Gene ID: (Mouse) 14773, (Rat) 59075, (Mouse) 59092
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
ATP binding
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
beta-adrenergic receptor kinase activity
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
desensitization of G-protein coupled receptor protein signaling pathway
protein phosphorylation
apoptotic process
signal transduction
tachykinin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
phosphorylation
termination of G-protein coupled receptor signaling pathway
negative regulation of apoptotic process
protein autophosphorylation
regulation of cell cycle
response to drug
negative regulation of mRNA splicing, via spliceosome
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
