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Invitrogen
GRPR Polyclonal Antibody
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产品信息
PA3-304
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues T(364) N P S V A T F S L I N G N I C H E R Y V(384) of human GRP-R receptor protein.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA3-304 detects GRP-R/ BB2 in human samples.
PA3-304 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects a broad ~65 kDa band representing the various glycosylated forms of GRP-R.
The PA3-304 immunogen is a synthetic peptide corresponding to residues T(364) N P S V A T F S L I N G N I C H E R Y V(384) of human GRP-R receptor protein.
靶标信息
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
