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NeoBiotechnologies
Galectin-9 (LGALS9) (Marker of T-Cell Exhaustion) Monoclonal Antibody (LGALS9/7689)
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产品信息
3965-MSM5-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2, kappa
分类
Monoclonal
类型
Antibody
克隆号
LGALS9/7689
抗原
Recombinant fragment (around aa 200-355) of human LGALS9 protein (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cytoplasm.
Positive control: Colon: A strong immunostaining is seen in all epithelial cells. Tonsil: A moderate to strong immunostaining occurs in the basal cell layer of the squamous epithelium of the tonsil surface.
Tissue specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
靶标信息
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H and RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ecalectin; Gal-9; Gal9; Galectin-9; Galectin9; HOM HD 21; lectin, galactoside binding soluble 9; lectin, galactoside-binding, soluble, 9; Tumor antigen HOM-HD-21; urate transporter/channel protein
基因别名: HUAT; LGALS9; LGALS9A
UniProt ID: (Human) O00182
Entrez Gene ID: (Human) 3965
natural killer cell tolerance induction
chemotaxis
inflammatory response
female pregnancy
positive regulation of gene expression
negative regulation of gene expression
response to lipopolysaccharide
regulation of interleukin-4 production
regulation of interleukin-5 production
negative regulation of chemokine production
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-4 production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
p38MAPK cascade
positive regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of mast cell degranulation
negative regulation of natural killer cell mediated cytotoxicity
negative regulation of activated T cell proliferation
positive regulation of viral entry into host cell
positive regulation of interleukin-1 beta secretion
positive regulation of NF-kappaB transcription factor activity
maternal process involved in female pregnancy
positive regulation of activated T cell autonomous cell death
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
cellular response to interferon-gamma
positive regulation of transforming growth factor beta production
positive regulation of monocyte chemotactic protein-1 production
mature conventional dendritic cell differentiation
cellular response to virus
regulation of p38MAPK cascade
positive regulation of interferon-gamma secretion
positive regulation of tumor necrosis factor secretion
positive regulation of interleukin-8 secretion
positive regulation of dendritic cell chemotaxis
negative regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of interleukin-13 secretion
positive regulation of dendritic cell apoptotic process
positive regulation of interleukin-6 secretion
positive regulation of interleukin-10 secretion
positive regulation of interleukin-12 secretion
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
positive regulation of dendritic cell differentiation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
