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Invitrogen
Glycine Binding Protein Polyclonal Antibody
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产品信息
PA3-100
应用
建议稀释比
已发表文章
产品规格
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the glycine-binding region residues S(140) Q V D L L A R L L R D L G(153) C of rat GBP.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA3-100 detects the glycine-binding protein.
PA3-100 has been used successfully in Western blot, ELISA, immunohistochemistry, immunocytochemistry, and immunoprecipitation procedures. In Western blot analysis of rat brain synaptic membranes this antibody detects a ~60 kDa protein representing glycine-binding protein.
The PA3-100 immunogen is a synthetic peptide corresponding to the glycine-binding region residues S(140) Q V D L L A R L L R D L G(153) C of rat GBP.
靶标信息
Ionotropic glutamate receptors are oligomeric ion channel proteins, which mediate fast neurotransmission and excitatory synapses in the mammalian central nervous system. There are three distinct subfamilies, of which NMDA receptors have received particular attention because they are implicated in both synaptic plasticity and the pathogenesis of acute and chronic neurodegenerative disorders. A unique feature of the NMDA receptors is their requirement for both glutamate and the co-agonist glycine for efficient gating. Glycine increases the affinity of the receptor for the endogenous agonist glutamate. The glycine binding site is found on the NR1 subunit of the NMDA receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
