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Invitrogen
Glypican 2 Polyclonal Antibody
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产品信息
PA5-48007
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human Glypican 2 Pro18-Ser553
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, approximately 45% cross-reactivity with recombinant mouse Glypican 2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Glypican 2 (GPC2) is a gene located on chromosome 7q22.1, encoding a member of the glypican family of heparan sulfate proteoglycans that are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Glypicans are involved in the regulation of cell growth, differentiation, and morphogenesis, primarily through their interactions with growth factors and morphogens in the extracellular environment. GPC2 is prominently expressed in the nervous system and plays a significant role in neural development, influencing processes such as neuronal growth and axon guidance. Alterations in GPC2 expression have been linked to neurodevelopmental disorders and certain cancers, such as neuroblastoma, where it can act as an oncofetal antigen. GPC2 is being investigated for its potential as a therapeutic target and biomarker in oncology due to its involvement in tumorigenesis and cancer progression. Research continues to explore its functional mechanisms and its implications in both neurobiology and cancer therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cerebroglycan; cerebroglycan proteoglycan; glypican proteoglycan 2, cerebroglycan proteoglycan; Glypican-2
基因别名: GPC2
UniProt ID: (Human) Q8N158
Entrez Gene ID: (Human) 221914
