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Invitrogen
HACE1 Polyclonal Antibody
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HACE1 Antibody (PA5-117159) in IHC (P)
Immunohistochemistry analysis of HACE1 in paraffin-embedded human placenta. Samples were incubated with HACE1 Polyclonal antibody (Product # PA5-117159) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-117159
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HACE1 (NP_0658222)
偶联物
形式
Liquid
浓度
0.65 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: 293T, HeLa, Mouse brain, Mouse lung, Mouse spleen, Mouse testis
Immunogen sequence: MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT
靶标信息
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase HACE1; hace 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1
基因别名: 1700042J16Rik; A730034A22Rik; BC025474; HACE1; KIAA1320; SPPRS
UniProt ID: (Human) Q8IYU2, (Rat) D3ZBM7, (Mouse) Q3U0D9
Entrez Gene ID: (Human) 57531, (Rat) 361866, (Mouse) 209462
ubiquitin-protein transferase activity
protein binding
ligase activity
Rab GTPase binding
Rac GTPase binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
transcription, DNA-templated
regulation of transcription, DNA-templated
Golgi organization
cell cycle
protein ubiquitination
Rac protein signal transduction
regulation of cell migration
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
membrane fusion
protein K48-linked ubiquitination
