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Invitrogen
HAMP Polyclonal Antibody
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HAMP Antibody (PA5-90884) in WB
Western blot analysis of HAMP in extracts of MDA-MB-435 cells. Samples were incubated with HAMP Polyclonal antibody (Product # PA5-90884) followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
产品信息
PA5-90884
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human Hepcidin (NP_0669981)
偶联物
形式
Liquid
浓度
4.11 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM PMFQRRRRRD THFPICIFCC GCCHRSKCGM CCKT; Positive Samples: MDA-MB-435
靶标信息
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hepcidin; hepcidin antimicrobial peptide 1; LEAP-1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor
基因别名: HAMP; Hamp1; HEPC; Hepc1; HFE2B; LEAP1; PLTR; UNQ487/PRO1003
UniProt ID: (Human) P81172, (Mouse) Q9EQ21
Entrez Gene ID: (Human) 57817, (Mouse) 84506
negative regulation of transcription from RNA polymerase II promoter
cellular iron ion homeostasis
immune response
response to iron ion
killing of cells of other organism
defense response to bacterium
defense response to fungus
multicellular organismal iron ion homeostasis
negative regulation of intestinal absorption
myeloid cell homeostasis
JAK-STAT cascade
negative regulation of iron ion transmembrane transport
positive regulation of macrophage activation
negative regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
iron ion homeostasis
positive regulation of cellular protein catabolic process
