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PA1-20319 detects HAND1 in mouse and rat samples. Antibody is expected to cross-react with human (100%) and rabbit (92%) based on sequence homology.
PA1-20319 has been successfully used in immunohistochemistry and Western blot procedures.
Positive control: Embryonic mouse brain.
The PA1-20319 immunogen is a synthetic peptide, BSA conjugated, correspondiong to the residues K(168) A D G G R E S K R K R E L(181) of to human HAND1.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
HAND1 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。