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Proteintech
HBP1 Polyclonal Antibody
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产品信息
11746-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
HBP1 Fusion Protein Ag2342 (215-514 aa encoded by BC022329)
偶联物
形式
Liquid
浓度
0.09 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This is a rabbit polyclonal antibody raised against the C-terminus of human HBP1.
Immunogen sequence: FLKGTRLCF HKGSNKEWQD VEDFARAEGC DNEEDLQMGI HKGYGSDGLK LLSHEESVSF GESVLKLTFD PGTVEDGLLT VECKLDHPFY VKNKGWSSFY PSLTVVQHGI PCCEVHIGDV CLPPGHPDAI NFDDPGVFDT FKSYDFTPMD SSAVYVLSSM ARQRRASLSC GGPGGQDFAR SGFSKNCGSP GSSQLSSNSL YAKAVKNHSS GTVSATSPNK CKRPMNAFML FAKKYRVEYT QMYPGKDNRA ISVILGDRWK KMKNEERRMY TLEAKALAEE QKRLNPDCWK RKRTNSGSQQ H (215-514 aa encoded by BC022329)
靶标信息
The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, which are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, that mediates DNA binding. HBP1 binds to the tumor suppressor proteins Rb and p130 and initiates cell cycle arrest. Terminal cell differentiation requires this initial cell cycle arrest followed by the coordinated expression of genes defined as tissue-specific markers. Along with initiating the commitment to cell differentiation, the continued activity of HBP1 abrogates the expression of tissue-specific genes by associating with the MyoD proteins. In muscle cell differentiation, the MyoD family of transcription factors, which include Myf5, MyoD and myogenein, induce the expression of these cell-type specific proteins and contribute to the development of cell phenotypes. The progression of terminal differentiation is, therefore, dependent on both a decrease in HBP1 activity and the corresponding activation of MyoD-induced gene transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: High mobility group box transcription factor 1; HMG box transcription factor 1; HMG box-containing protein 1
基因别名: 1700058O05Rik; BE629963; C330012F01Rik; C86454; HBP1
UniProt ID: (Human) Q8TBM1, (Mouse) Q8R316
Entrez Gene ID: (Human) 26959, (Mouse) 73389
