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Invitrogen
HCN1 Monoclonal Antibody (RTQ 7C3), eBioscience™
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图: 1 / 2
HCN1 Antibody (14-5691-82) in WB
Western Blot analysis was performed on whole cell extracts of Rat Brain (Lane 1), Mouse Brain (Lane 2) and HEK-293T(Lane 3) cells. The proteins were separated on a 4-12% Nupage Bis-Tris Gel (Product # NP0336BOX) using MOPS SDS Running Buffer (Product # NP0001-02). Protein transfer to a PVDF membrane (Product # IB24002) was achieved using the iBlot 2 system. Subsequently, the membrane was blocked with 5% milk and probed overnight at 4 C with 1.0 µg/mL Anti-Mouse/Rat HCN1 Monoclonal Antibody (clone RTQ-7C3), followed by Goat anti-Rat IgG Sec... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
14-5691-82
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rat
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
RTQ 7C3
抗原
aa 650 - 685 of rat HCN1
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: This RTQ 7C3 monoclonal antibody recognizes mouse and rat HCN1. Clone RTQ 7C3 detects a ~110 kDa band corresponding to HCN1 by Western Blot.
Applications Reported: This RTQ 7C3 antibody has been reported for use in western blot.
Applications Tested: This RTQ 7C3 antibody has been tested by western blot of mouse and rat tissue lysates. This may be used at less than or equal to 1 µg/mL.
靶标信息
HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCNG-1; brain cyclic nucleotide-gated channel 1; HAC-2; hyperpolarization-activated cation channel 2; hyperpolarization-activated, cyclic nucleotide-gated K+ 1
基因别名: Bcng1; C630013B14Rik; HAC2
UniProt ID: (Mouse) O88704, (Rat) Q9JKB0
Entrez Gene ID: (Mouse) 15165, (Rat) 84390
ion channel activity
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
voltage-gated cation channel activity
cAMP binding
identical protein binding
regulation of membrane depolarization
ion transport
potassium ion transport
neuronal action potential
cellular response to interferon-beta
sodium ion transmembrane transport
regulation of membrane potential
maternal behavior
apical protein localization
negative regulation of action potential
retinal cone cell development
protein homotetramerization
response to calcium ion
general adaptation syndrome, behavioral process
transmembrane transport
regulation of postsynaptic membrane potential
cellular response to cAMP
potassium ion transmembrane transport
response to L-glutamate
regulation of membrane hyperpolarization
positive regulation of membrane hyperpolarization
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