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HCN4 Monoclonal Antibody (N114/10)
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图: 1 / 2
HCN4 Antibody (200-301-F43) in IHC (F)
Immunohistochemistry of mouse anti-HCN4 antibody. Tissue: mouse brain. Fixation: frozen. Primary Antibody: HCN4 antibody at 1 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase mouse secondary at 1:10,000 for 45 min at RT. Localization: Nuclear. Staining: HCN4 as precipitated red signal with hematoxylin purple nuclear counterstain.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
200-301-F43
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N114/10
抗原
HCN4 Antibody was produced in mice by repeated immunizations with a fusion protein corresponding to the C terminus region of rat HCN4.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS, pH 7.2, with 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
HCN4 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain cyclic nucleotide-gated channel 3; HAC-4; hyperpolarization activated cation channel; hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization-activated cation channel 4; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4
基因别名: Bcng3; BRGDA8; EIG18; HAC4; Hcn3; SSS2
UniProt ID: (Human) Q9Y3Q4, (Rabbit) Q9TV66, (Rat) Q9JKA7, (Mouse) O70507
Entrez Gene ID: (Human) 10021, (Rabbit) 100009452, (Rat) 59266, (Mouse) 330953
ion channel activity
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
sodium channel activity
protein binding
identical protein binding
voltage-gated potassium channel activity involved in SA node cell action potential depolarization
potassium channel activity
ion channel
transporter
regulation of heart rate
sinoatrial node development
regulation of membrane depolarization
ion transport
cation transport
potassium ion transport
muscle contraction
blood circulation
sodium ion transmembrane transport
regulation of membrane potential
transmembrane transport
regulation of cardiac muscle contraction
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
membrane depolarization during cardiac muscle cell action potential
SA node cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
sodium ion import across plasma membrane
regulation of SA node cell action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
potassium ion import across plasma membrane
in utero embryonic development
regulation of heart contraction
modulation of synaptic transmission
cellular response to aldosterone
Disclaimer
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