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MA3-903 detects HCN4 from human, mouse, and rat samples.
MA3-903 has been successfully used in Western blotting and immunohistochemistry procedures. By Western blot MA3-903 detects a ~132 KDa band representing HCN4.
The MA3-903 immunogen is a synthetic peptide sequence corresponding to residues S H G S L L L P P A S S P P P P Q V P Q R R G T P P L T P G R L T Q D L K L of HCN4.
MA3-903 clone SHG 1E5 is a rat monoclonal hybridoma. This antibody was produced by immunizing a rat, isolating the spleen cells, creating the hybridoma and successively injecting these cells into a mouse to produce ascites.
HCN4 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BCNG-3; Brain cyclic nucleotide-gated channel 3; hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
基因别名: Bcng3; Hcn3; HCN4; SSS2
UniProt ID: (Human) Q9Y3Q4, (Mouse) O70507, (Rat) Q9JKA7
Entrez Gene ID: (Human) 10021, (Mouse) 330953, (Rat) 59266