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Invitrogen
HDAC3 Recombinant Superclonal™ Antibody
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HDAC3 Antibody (711470) in WB
Western blot analysis was performed on Whole cell extracts (30 µg lysate) of HeLa (Lane 1), C2C12 (Lane 2), COS-7 (Lane 3), Hep G2 (Lane 4), A-431 (Lane 5), MCF7 (Lane 6) and Tissue extracts of Mouse Brain (Lane 7), Rat Brain (Lane 8) and Mouse Liver (Lane 9). The blots were probed with Anti-HDAC3 Recombinant Rabbit Superclonal™ Antibody (Product # 711470, 1-2 µg/mL). A 48 kDa band corresponding to HDAC3 was observed across the cell lines and tissues tested. The blots were detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Cha... View More
产品信息
711470
产品规格
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
抗原
Protein corresponding to human HDAC3 (aa311-aa428)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Pig, Rat, Dog
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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