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Invitrogen
HDAC5 Polyclonal Antibody
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产品信息
PA5-79352
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human HDAC5 (626-644aa YKKLFSDAQPLQPLQVYQA).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA Cell, COLO320 Cell.
靶标信息
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen NY-CO-9; DKFZp779K1053; FLJ90614; HD5; HD7; HD7b; HD9; HDAC; HDAC-5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4; Histone deacetylase 5; histone deacetylase mHDA1; KIAA0744
基因别名: AI426555; HD5; Hdac4; HDAC5; KIAA0600; mHDA1; mKIAA0600; NY-CO-9
UniProt ID: (Human) Q9UQL6
Entrez Gene ID: (Human) 10014, (Rat) 84580, (Mouse) 15184
RNA polymerase III transcription factor binding
core promoter binding
chromatin binding
histone deacetylase activity
protein kinase C binding
protein binding
transcription factor binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
histone deacetylase binding
transcription regulatory region DNA binding
metal ion binding
repressing transcription factor binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcription corepressor activity
protein kinase binding
hydrolase activity
histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
chromatin silencing
transcription, DNA-templated
protein deacetylation
inflammatory response
regulation of myotube differentiation
negative regulation of myotube differentiation
response to activity
chromatin modification
histone deacetylation
neuron differentiation
B cell differentiation
cellular response to insulin stimulus
regulation of gene expression, epigenetic
B cell activation
response to cocaine
response to drug
regulation of protein binding
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
histone H3 deacetylation
cellular response to lipopolysaccharide
negative regulation of cell migration involved in sprouting angiogenesis
regulation of histone H3-K9 acetylation
osteoblast development
transcription from RNA polymerase II promoter
heart development
multicellular organismal response to stress
negative regulation of osteoblast differentiation
regulation of skeletal muscle fiber development
regulation of striated muscle cell differentiation
renal tubule morphogenesis
cellular response to fluid shear stress
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation
regulation of transcription, DNA-templated
nervous system development
negative regulation of gene expression
negative regulation of striated muscle tissue development
