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Invitrogen
HELLS Recombinant Rabbit Monoclonal Antibody (6J1O2)
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FIGURE: 1 / 4
HELLS Antibody (MA5-51270) in IHC (P)
Immunohistochemistry analysis of HELLS in paraffin-embedded human tonsil. Samples were incubated with HELLS Recombinant monoclonal antibody (Product # MA5-51270) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
MA5-51270
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6J1O2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 614-838 of human Lsh/HELLS (NP_060533.2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.1 mg/mL
Amount
110 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RGHKVLLFSQ MTSMLDILMD YCHLRDFNFS RLDGSMSYSE REKNMHSFNT DPEVFIFLVS TRAGGLGINL TAADTVIIYD SDWNPQSDLQ AQDRCHRIGQ TKPVVVYRLV TANTIDQKIV ERAAAKRKLE KLIIHKNHFK GGQSGLNLSK NFLDPKELME LLKSRDYERE IKGSREKVIS DKDLELLLDR SDLIDQMNAS GPIKEKMGIF KILENSEDSS PECLF
Target Information
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: helicase, lymphoid specific; hells; LSH; Lymphocyte-specific helicase; Lymphoid-specific helicase; Proliferation-associated SNF2-like protein; Senescence Associated Long Non-coding RNA; similar to Mus musculus lymphocyte specific helicase mRNA with GenBank Accession Number U25691.1; SMARCA6; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6; TBC1D12: TBC1 domain family, member 12; unnamed protein product
Gene Aliases: AI323785; E130115I21Rik; HELLS; ICF4; LSH; Lysh; Nbla10143; PASG; SALNR; SMARCA6; Tbc1d12; YFK8
UniProt ID: (Human) Q9NRZ9, (Mouse) Q60848
Entrez Gene ID: (Human) 3070, (Mouse) 15201, (Rat) 294071
double-strand break repair via homologous recombination
urogenital system development
kidney development
double-strand break repair
chromatin remodeling
methylation-dependent chromatin silencing
apoptotic process
heterochromatin assembly
pericentric heterochromatin assembly
negative regulation of apoptotic process
hypermethylation of CpG island
lymphocyte proliferation
cell division
chromosomal DNA methylation maintenance following DNA replication
cellular response to leukemia inhibitory factor
negative regulation of intrinsic apoptotic signaling pathway
DNA methylation
chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
mitotic nuclear division
multicellular organism development
maintenance of DNA methylation
lymphocyte differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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