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Invitrogen
HEY2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-67365
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PCEETTSESDM DETIDVGSEN NYSGQSTSSV IRLNSPTTTS QIMARKK
Highest antigen sequence identity to the following orthologs - mouse 88%, rat 90%.
靶标信息
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiovascular basic helix-loop-helix factor 1; cardiovascular helix-loop-helix factor 1; CHF1; class B basic helix-loop-helix protein 32; h hHRT2; hairy and enhancer of split-related protein 2; hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; hCHF1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hGRL; basic helix-loop-helix transcription factor; hHRT2; HRT-2; HRT2; protein gridlock homolog; transcription factor; unnamed protein product
基因别名: bHLHb32; CHF1; GRIDLOCK; GRL; HERP1; HESR2; HRT2
UniProt ID: (Human) Q9UBP5
Entrez Gene ID: (Human) 23493
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
histone deacetylase binding
sequence-specific DNA binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
muscular septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
aortic valve morphogenesis
pulmonary valve morphogenesis
tricuspid valve morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
cardiac ventricle morphogenesis
cardiac left ventricle morphogenesis
cardiac right ventricle morphogenesis
regulation of transcription, DNA-templated
Notch signaling pathway
heart development
anatomical structure morphogenesis
anterior/posterior pattern specification
negative regulation of gene expression
mesenchymal cell development
ascending aorta morphogenesis
dorsal aorta morphogenesis
umbilical cord morphogenesis
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
smooth muscle cell differentiation
negative regulation of smooth muscle cell differentiation
ventricular cardiac muscle cell development
cardiac epithelial to mesenchymal transition
heart trabecula formation
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
negative regulation of transcription initiation from RNA polymerase II promoter
labyrinthine layer blood vessel development
arterial endothelial cell differentiation
pulmonary artery morphogenesis
negative regulation of biomineral tissue development
circulatory system development
vascular smooth muscle cell development
negative regulation of cardiac vascular smooth muscle cell differentiation
regulation of vasculogenesis
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