Proteintech

HEYL Polyclonal Antibody

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HEYL Polyclonal Antibody

产品信息

15679-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫细胞化学 (ICC/IF)

1:10-1:100
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免疫沉淀 (IP)

0.5-4.0 µg
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

HEYL Fusion Protein Ag8163 (1-328 aa encoded by BC006087)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MKRPKEPSG SDGESDGPID VGQEGQLSQM ARPLSTPSSS QMQARKKRRG IIEKRRRDRI NSSLSELRRL VPTAFEKQGS SKLEKAEVLQ MTVDHLKMLH ATGGTGFFDA RALAVDFRSI GFRECLTEVI RYLGVLEGPS SRADPVRIRL LSHLNSYAAE MEPSPTPTGP LAFPAWPWSF FHSCPGLPAL SNQLAILGRV PSPVLPGVSS PAYPIPALRT APLRRATGII LPARRNVLPS RGASSTRRAR PLERPATPVP VAPSSRAARS SHIAPLLQSS SPTPPGPTGS AAYVAVPTPN SSSPGPAGRP AGAMLYHSWV SEITEIGAF (1-328 aa encoded by BC006087 )

靶标信息

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: bHLHb33; Class B basic helix-loop-helix protein 33; hairy and enhance of split related 3; Hairy and enhancer of split-related protein 3; Hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; Hairy/enhancer-of-split related with YRPW motif-like protein; hes-related family bHLH transcription factor with YRPW motif-like; HEY-like protein; hHeyL; hHRT3; HRT-3; mHRT3

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基因别名: BHLHB33; HESR3; HEY3; HEYL; HRT3

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UniProt ID: (Human) Q9NQ87, (Mouse) Q9DBX7

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Entrez Gene ID: (Human) 26508, (Mouse) 56198, (Rat) 313575

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功能
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding transcription factor binding microsatellite binding protein homodimerization activity protein heterodimerization activity AF-1 domain binding DNA binding sequence-specific DNA binding protein dimerization activity basic helix-loop-helix transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis transcription from RNA polymerase II promoter Notch signaling pathway mesenchymal cell development glomerulus development skeletal muscle cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cardiac epithelial to mesenchymal transition ventricular septum morphogenesis negative regulation of androgen receptor signaling pathway cellular response to BMP stimulus proximal tubule development negative regulation of androgen receptor activity transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development peripheral nervous system development negative regulation of gene expression
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