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Invitrogen
HFE Polyclonal Antibody
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图: 1 / 5
HFE Antibody (PA5-102408) in ICC/IF
Immunofluorescent analysis of HFE in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and HFE polyclonal antibody (Product # PA5-102408) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102408
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HFE(Accession Q30201), corresponding to amino acid residues Q119-W169.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total HFE.
靶标信息
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin. It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hereditary hemochromatosis protein; Hereditary hemochromatosis protein homolog; HFE 1; HLA H; HLA-H; MGC10379; MGC103790; MGC:150812; RT1-CAFE
基因别名: HFE; HLAH; MR2
UniProt ID: (Rat) O35799, (Mouse) P70387
Entrez Gene ID: (Rat) 29199, (Mouse) 15216
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation of peptide antigen via MHC class I
cellular iron ion homeostasis
acute-phase response
immune response
female pregnancy
cellular response to iron ion starvation
antigen processing and presentation
hormone biosynthetic process
iron ion homeostasis
multicellular organismal iron ion homeostasis
liver regeneration
iron ion import into cell
response to iron ion starvation
immune system process
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of receptor binding
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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