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Invitrogen
HFE2 Polyclonal Antibody
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产品信息
PA5-145451
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human HJV protein, Gln36-Phe200 (Accession #Q6ZVN8)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% Proclin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DL M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile); hemochromatosis type 2 (juvenile) (human homolog); Hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; Hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; MGC23953; OTTHUMP00000059680; repulsive guidance molecule C; RGM C; RGM domain family member C
基因别名: 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL-M; hemojuvelin; HFE2; HFE2A; HJV; JH; RGMC
UniProt ID: (Human) Q6ZVN8, (Mouse) Q7TQ32
Entrez Gene ID: (Human) 148738, (Pig) 100155778, (Rat) 310681, (Mouse) 69585
biological_process
BMP signaling pathway
negative regulation of BMP signaling pathway
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
negative regulation of transcription from RNA polymerase II promoter
cellular iron ion homeostasis
protein autoprocessing
activin receptor signaling pathway
cellular response to BMP stimulus
