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Invitrogen
HIV1 nef Polyclonal Antibody
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产品信息
PA1-4961
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Nef protein
偶联物
形式
Liquid
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
PA1-4961 detects the HIV-1 Nef protein in HIV samples.
PA1-4961 has been successfully used in Western blot, IP, DB, and ELISA procedures. By Western blot this antibody detects a ~27 kDa protein, corresponding to HIV-1 Nef in HIV samples.
PA1-4961 immunogen corresponds to the recombinant Nef protein which was over-expressed in E. coli with a plasmid carrying the Nef coding region of HIV-1 virus.
Recombinant HIV-1 Nef protein (Cat. # RP-4922 or RP-4923) can be purchased for control experiments in Western blot assays.
靶标信息
HIV-1 Nef is one of the accessory proteins synthesized in the early stage of AIDS virus reproduction and is abundantly found in infected cells. The name derives from its negative factor thought at the beginning but presently it is remarked as the protein which bears a most distinctive biological characteristic of AIDS virus. The protein interacts directly with the signal transduction protein of the host T cell and works effectively on AIDS infection or on long term survival of the infected cells or induces apoptosis of non-infected cells. It is also involved in the endocytosis and degradation of receptor protein of the cell surface such as CD 4 and MH4, important for AIDS virus infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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