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Invitrogen
HKT288 Recombinant Human Monoclonal Antibody
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产品信息
MA562694
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
HKT288 is a biosimilar developed to target cadherin-6 (CDH6) also referred to as K-cadherin a cell adhesion molecule implicated in various cancers. It functions as an antibody-drug conjugate (ADC) that employs CDH6 targeting to deliver cytotoxic agents directly to tumor cells thereby enhancing selective antitumor activity. Structural optimization of HKT288 involves modifying linker components to improve its specificity and reduce off-target effects showcasing the importance of linker choice in ADC design for enhanced clinical outcomes. This biosimilar is used in research settings as a recombinant monoclonal antibody and its applications in flow cytometry demonstrate a high affinity for CDH6 reinforcing its effectiveness in binding assays critical for cancer therapy development. Studies highlight both its function and its limitations such as potential neurotoxicity indicating cautious advancement in clinical use and the need for further investigations into its molecular mechanisms and therapeutic potential.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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