Leinco Technologies

HLA A2,B7 (MHC Class I) Monoclonal Antibody (BB7.6), Functional Grade, In Vivo GOLD™

Name: HLA A2,B7 (MHC Class I) Monoclonal Antibody (BB7.6), Functional Grade, In Vivo GOLD\u2122
Brand: Leinco Technologies
SKU: H1685-100MG

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

产品信息

H1685-100MG

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-dependent

功能检测 (Functional)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

BB7.6

抗原

Solubilized HLA-B7 antigen

偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

≥5.0 mg/mL

100 mg

纯化类型

Protein A/G

保存液

PBS, pH 7.2-7.4

内含物

no preservative

保存条件

4°C short term, -80°C long term

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Specificity: Clone BB7.6 recognizes an epitope shared by the human MHC class I molecule HLA-B.

Endotoxin Level: <1.0 EU/mg as determined by the LAL method.

Purity: ≥95% monomer by analytical SEC and >95% by SDS Page.

Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles.

靶标信息

HLA-A2 and HLA-B7 are human leukocyte antigen (HLA) class I proteins that are involved in the presentation of antigens to T cells. They are composed of a heavy chain and a light chain, which are both anchored to the cell membrane. The heavy chain consists of three domains: alpha-1, alpha-2, and alpha-3. The alpha-1 and alpha-2 domains form a peptide-binding groove that can accommodate peptides of different lengths and sequences. The light chain, also known as beta-2 microglobulin, is non-covalently associated with the heavy chain and stabilizes its structure. HLA-A2 and HLA-B7 proteins are located on the surface of most nucleated cells in the body and present peptides derived from intracellular proteins to CD8+ T cells. This process is essential for the recognition and elimination of infected or cancerous cells by the immune system. HLA-A2 and HLA-B7 proteins are highly polymorphic, meaning that they can vary in their amino acid sequences between individuals. This diversity allows the immune system to recognize a wide range of antigens and mount an effective immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: allele B-3515; B*3509; cell surface glycoprotein; integral membrane protein; glycosylation aa 86, alpha domain 1 aa 1-24, alpha domain 2 aa 25-114, alpha domain 3 aa 207-298; glycosylation aa 86, alpha domain 1 aa 25-114, alpha domain 2 aa 115-206, alpha domain 3 aa 207-298; heavy chain; hla antigen; HLA B-1519; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA class I histocompatibility antigen, B alpha chain; HLA protein allele A25; HLA protein allele B37; HLA protein allele B51; HLA protein allele B57; HLA protein allele B7; HLA-A; HLA-A 2402; HLA-A*0201 alpha chain; human leukocyte antigen; HLA-A*0204; HLA-A*0207 alpha chain; human leukocyte antigen; HLA-A-0102 allele; HLA-A24AK; HLA-A25; HLA-B; HLA-B*4002; HLA-B-07ZEL allele; HLA-B-1501; HLA-B-1516; HLA-B-1520 allele; HLA-B-15AOH allele; HLA-B-15ZEL allele; HLA-B-27KSH allele; HLA-B-67LAV allele; This submission reports an HLA-B-6701 variant (HLA-B-67LAV) that differs from the published B-6701 sequence, GenBank Accession Number L17005; HLA-B18; HLA-B27 peptide; HLA-B39; HLA-B41 variant; HLA-B61; HLA-Bw-39-DBU allele; human leukocyte antigen; Human leukocyte antigen A; Human leukocyte antigen B; leukocyte antigen class I-A; leukocyte antigen class I-B; lymphocyte antigen; major histocompatibility complex class I A; MHC class 1 antigen; MHC class I antigen HLA-A heavy chain; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I molecule; MHC class I-like alpha chain membrane-bound type; MHC HLA-A cell surface antigen; MHC HLA-A10-alpha-2 chain precursor; MHC HLA-A2.4a chain; MHC HLA-A24 cell surface glycoprotein; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B44; MHC HLA-B7 heavy chain precursor; MHC HLA-Bw46; similar to Homo sapiens MHC HLA-B39 mRNA with GenBank Accession Number L42024.1; subtype B*3508 differs at residue 156 (Leu->Arg) with subtype B*3501; unnamed protein product

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基因别名: AS; B-4901; HLA-A; HLA-B; HLAA; HLAB

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UniProt ID: (Human) P04439, (Human) P01889

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Entrez Gene ID: (Human) 3105, (Human) 3106

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