Leinco Technologies

HLA A2,B7 (MHC Class I) Monoclonal Antibody (BB7.6), Functional Grade, In Vivo GOLD™

Name: HLA A2,B7 (MHC Class I) Monoclonal Antibody (BB7.6), Functional Grade, In Vivo GOLD\u2122
Brand: Leinco Technologies
SKU: H1685-100MG

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

H1685-100MG

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-dependent

功能检测 (Functional)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

BB7.6

抗原

Solubilized HLA-B7 antigen

偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

≥5.0 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.2-7.4

内含物

no preservative

保存条件

4°C short term, -80°C long term

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Specificity: Clone BB7.6 recognizes an epitope shared by the human MHC class I molecule HLA-B.

Endotoxin Level: <1.0 EU/mg as determined by the LAL method.

Purity: ≥95% monomer by analytical SEC and >95% by SDS Page.

Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles.

靶标信息

HLA-A2 and HLA-B7 are human leukocyte antigen (HLA) class I proteins that are involved in the presentation of antigens to T cells. They are composed of a heavy chain and a light chain, which are both anchored to the cell membrane. The heavy chain consists of three domains: alpha-1, alpha-2, and alpha-3. The alpha-1 and alpha-2 domains form a peptide-binding groove that can accommodate peptides of different lengths and sequences. The light chain, also known as beta-2 microglobulin, is non-covalently associated with the heavy chain and stabilizes its structure. HLA-A2 and HLA-B7 proteins are located on the surface of most nucleated cells in the body and present peptides derived from intracellular proteins to CD8+ T cells. This process is essential for the recognition and elimination of infected or cancerous cells by the immune system. HLA-A2 and HLA-B7 proteins are highly polymorphic, meaning that they can vary in their amino acid sequences between individuals. This diversity allows the immune system to recognize a wide range of antigens and mount an effective immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: A29 protein; antigen presenting molecule; class I MHC, HLA-B antigen; epididymis secretory protein Li 83; histocompatibility antigen; HLA -B; HLA A; HLA B-40011; HLA B44; HLA class I antigen; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-30 alpha chain; HLA class I histocompatibility antigen, A-33 alpha chain; HLA class I histocompatibility antigen, A-74 alpha chain; HLA class I histocompatibility antigen, B alpha chain; HLA class I histocompatibility antigen, B-47 alpha chain; HLA class I histocompatibility antigen, B-50 alpha chain; HLA class I histocompatibility antigen, B-82 alpha chain; HLA locus; HLA molecule; HLA-A; HLA-A locus alpha 2 domain; HLA-A null; HLA-Aw33.1; HLA-B; HLA-B alpha chain; HLA-B alpha chain (B*2706); HLA-B alpha chain (B*5002); HLA-B alpha-chain; HLA-B35; HLA-B35 antigen; HLA-Bw50 antigen; Human leukocyte antigen A; Human leukocyte antigen B; hypothetical protein; lecocyte antigen B; Leukocyte Antigen; leukocyte antigen class I-A; leukocyte antigen class I-B; Leukoocyte Antigen; lymphocyte antigen; major histocompatability complex B antigen; MCH class I antigen; MHC antigen; MHC class 1 antigen; MHC class I alpha chain; MHC class I anitgen; MHC class I anti; MHC Class I antigen; MHC class I antigen A*30; MHC class I antigen A*33; MHC class I antigen A*74; MHC class I antigen B*47; MHC class I antigen B*50; MHC class I antigen B*82; MHC class I antigen GN00104; MHC class I antigen heavy chain; MHC class I antigen HLA-A heavy chain; MHC class I antigen HLA-A33; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen null protein; MHC class I antigen SHCHA; MHC class I antigene; MHC class I human leukocyte antigen; MHC class I molecule; MHC class I protein; MHC class II antigen; MHC class l antigen; MHC classI antigen; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B27-HS; MHC HLA-B27d; MHC HLA-B39N; truncated class I antigen; truncated MHC class I antigen

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基因别名: AS; Aw-33; Aw-74; B-4901; B-5001; Bw-47; Bw-50; HEL-S-83; HLA-A; HLA-A11; HLA-A33; HLA-B; HLA-B*45ZJ; HLA-B-3506; HLA-B-3905; HLA-B-5502; HLA-B-5602; HLA-B15; HLA-B39; HLA-B49; HLA-B50; HLA-B55; HLA-B59; HLA-B61; HLA-Cw; HLA-DQB1; HLA-DRB1; HLAA; HLAB; SPDA1

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UniProt ID: (Human) Q95380, (Human) Q29678

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Entrez Gene ID: (Human) 3105, (Human) 3106

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功能

protein binding beta-2-microglobulin binding peptide antigen binding poly(A) RNA binding antigen binding major histocompatibility complex protein

参与通路

antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent viral process antigen processing and presentation regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway