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Invitrogen
HLA-F Monoclonal Antibody (3D11), PE
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HLA-F Antibody (MA574580) in Flow
Flow cytometry analysis of HLA-F in human lymphocytes (red); mouse IgG1 isotype control (black-dashed). Samples were incubated with monoclonal HLA-F (Product # MA574580) using a dilution of 5 μg/mL (HLA-F, red); 10 µL reagent/100 µL of peripheral whole blood (CD20), followed by PE.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA574580
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3D11
抗原
Inclusion body-derived HLA-F heavy chain.
偶联物
PE
PE
PE
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
规格
100 µg
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
HLA-F belongs to the HLA class I heavy chain paralogues. It is a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HLA F antigen; HLA-F; leukocyte antigen F; MHC class I antigen F; non-classical; non-classical MHC class I antigen; nonclassical MHC class I antigen; unnamed protein product
基因别名: CDA12; HLA-5.4; HLA-CDA12; HLAF
UniProt ID: (Human) P30511
Entrez Gene ID: (Human) 3134
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of exogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
regulation of natural killer cell mediated immunity
negative regulation of T cell cytokine production
negative regulation of natural killer cell cytokine production
positive regulation of natural killer cell cytokine production
immune response
negative regulation of natural killer cell degranulation
positive regulation of natural killer cell degranulation
negative regulation of natural killer cell mediated cytotoxicity
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