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Proteintech
HMHA1 Polyclonal Antibody
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产品信息
14832-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
HMHA1 Fusion Protein Ag6636 (804-1136 aa encoded by BC065223)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: RVEKLCQAF ENGKELVELS QASPHDISNV LKLYLRQLPE PLISFRLYHE LVGLAKDSLK AEAEAKAASR GRQDGSESEA VAVALAGRLR ELLRDLPPEN RASLQYLLRH LRRIVEVEQD NKMTPGNLGI VFGPTLLRPR PTEATVSLSS LVDYPHQARV IETLIVHYGL VFEEEPEETP GGQDESSNQR AEVVVQVPYL EAGEAVVYPL QEAAADGCRE SRVVSNDSDS DLEEASELLS SSEASALGHL SFLEQQQSEA SLEVASGSHS GSEEQLEATA REDGDGDEDG PAQQLSGFNT NQSNNVLQAP LPPMRLRGGR MTLGSCRERQ PEFV (804-1136 aa encoded by BC065223)
靶标信息
Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domain which is able to play an autoinhibitory effect on this RhoGAP activity. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: histocompatibility (minor) HA-1; minor histocompatibility antigen HA-1; Minor histocompatibility protein HA-1; Rho GTPase-activating protein 45
基因别名: 6330406L22Rik; ARHGAP45; AW539505; HA-1; HLA-HA1; HMHA1; KIAA0223; RGD1308662
UniProt ID: (Human) Q92619, (Mouse) Q3TBD2
Entrez Gene ID: (Human) 23526, (Rat) 314618, (Mouse) 70719
