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Proteintech
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Immunogen sequence: MASSMRSLF SDHGKYVESF RRFLNHSTEH QCMQEFMDKK LPGIIGRIGD TKSEIKILSI GGGAGEIDLQ ILSKVQAQYP GVCINNEVVE PSAEQIAKYK ELVAKTSNLE NVKFAWHKET SSEYQSRMLE KKELQKWDFI HMIQMLYYVK DIPATLKFFH SLLGTNAKML IIVVSGSSGW DKLWKKYGSR FPQDDLCQYI TSDDLTQMLD NLGLKYECYD LLSTMDISDC FIDGDENGDL LWDFLTETCN FNATAPPDLR AELGKDLQEP EFSAKKEGKV LFNNTLSFIV IEA (1-292 aa encoded by BC020677)
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Histamine N-methyltransferase; HMT
基因别名: 1500031F01Rik; AI788969; HMT; HNMT; HNMT-S1; HNMT-S2; MRT51
UniProt ID: (Human) P50135, (Mouse) Q91VF2, (Rat) Q01984
Entrez Gene ID: (Human) 3176, (Mouse) 140483, (Rat) 81676