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Invitrogen
HOPX Polyclonal Antibody
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产品信息
PA5-114744
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Fish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HOPX(Accession Q9BPY8), corresponding to amino acid residues A40-D73.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total HOP.
靶标信息
HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: homeobox only domain; Homeobox-only protein; homeodomain only protein; Homeodomain-only protein; Lung cancer-associated Y protein; mOB1; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; odd homeobox 1; Odd homeobox protein 1
基因别名: 1110018K11Rik; 1200015P04Rik; 2300002F06Rik; AI848177; AW490897; CAMEO; Hdop; HOD; HOP; HOPX; LAGY; NECC1; OB1; Obl; SMAP31; TOTO
UniProt ID: (Human) A8K0Z2, (Mouse) Q8R1H0
Entrez Gene ID: (Human) 84525, (Mouse) 74318
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
heart development
regulation of heart contraction
histone deacetylation
regulation of protein binding
positive regulation of skeletal muscle tissue regeneration
negative regulation of cell differentiation
lung alveolus development
positive regulation of striated muscle cell differentiation
regulation of transcription from RNA polymerase II promoter
