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Proteintech
HSPH1 Polyclonal Antibody
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产品信息
13383-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
HSPH1 Fusion Protein Ag4224 (508-858 aa encoded by BC037553)
偶联物
形式
Liquid
浓度
0.39 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody recognizes both HSP105alpha and HSP105beta isoforms. Western blot analysis using this antibody detected a major band around 100-110kD in Jurkat cells.
Immunogen sequence: MSSEADMEC LNQRPPENPD TDKNVQQDNS EAGTQPQVQT DAQQTSQSPP SPELTSEENK IPDADKANEK KVDQPPEAKK PKIKVVNVEL PIEANLVWQL GKDLLNMYIE TEGKMIMQDK LEKERNDAKN AVEEYVYEFR DKLCGPYEKF ICEQDHQNFL RLLTETEDWL YEEGEDQAKQ AYVDKLEELM KIGTPVKVRF QEAEERPKMF EELGQRLQHY AKIAADFRNK DEKYNHIDES EMKKVEKSVN EVMEWMNNVM NAQAKKSLDQ DPVVRAQEIK TKIKELNNTC EPVVTQPKPK IESPKLERTP NGPNIDKKEE DLEDKNNFGA EPPHQNGECY PNEKNSVNMD LD (508-858 aa encoded by BC037553)
靶标信息
HSPH1 prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. This protein inhibits HSPA8/HSC70 ATPase and chaperone activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Antigen NY-CO-25; heat shock 105kD alpha; heat shock 105kD beta; heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; Heat shock protein; Heat shock protein 105 kDa; Heat shock protein family H member 1; HSP; NY CO 25
基因别名: HSP105; HSP105A; HSP105B; HSP110; HSPH1; KIAA0201; NY-CO-25
UniProt ID: (Human) Q92598
Entrez Gene ID: (Human) 10808
receptor-mediated endocytosis
response to unfolded protein
positive regulation of MHC class I biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
chaperone mediated protein folding requiring cofactor
positive regulation of NK T cell activation
positive regulation of protein tyrosine kinase activity
regulation of cellular response to heat
negative regulation of establishment of protein localization to mitochondrion
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
negative regulation of p38MAPK cascade
