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NeoBiotechnologies
Hepatocyte nuclear factor 1 beta (HNF1b)/Transcription Factor 2 (TCF2) Monoclonal Antibody (HNF1B/9519)
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Hepatocyte nuclear factor 1 beta (HNF1b)/Transcription Factor 2 (TCF2) Antibody (6928-MSM2-P1ABX) in IHC (P)
Formalin-fixed, paraffin-embedded human liver carcinoma stained with HNF1B Mouse Monoclonal Antibody (HNF1B/9519). Inset: PBS instead of primary antibody; secondary only negative control.
产品信息
6928-MSM2-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
HNF1B/9519
抗原
Recombinant fragment (around aa 1-200) of human HNF1B protein (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Nucleus.
Positive control: Human kidney, pancreas or liver tissue.
靶标信息
Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF1 beta A; Homeoprotein LFB3; TCF-2; Transcription factor 2; transcription factor 2, hepatic; Variant hepatic nuclear factor 1; vHNF1
基因别名: FJHN; HNF-1-beta; HNF-1B; HNF1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1
UniProt ID: (Human) P35680
Entrez Gene ID: (Human) 6928
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter proximal region DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
protein complex binding
protein homodimerization activity
protein heterodimerization activity
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate specification
kidney development
inner cell mass cell differentiation
transcription, DNA-templated
Notch signaling pathway
response to glucose
anterior/posterior pattern specification
response to organic cyclic compound
insulin secretion
regulation of Wnt signaling pathway
hindbrain development
circadian regulation of gene expression
regulation of pronephros size
pronephric nephron tubule development
response to drug
regulation of endodermal cell fate specification
positive regulation of transcription, DNA-templated
embryonic digestive tract morphogenesis
branching morphogenesis of an epithelial tube
pronephros development
epithelial cell proliferation
positive regulation of transcription initiation from RNA polymerase II promoter
ureteric bud elongation
hepatoblast differentiation
negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
protein-DNA complex assembly
hepatocyte differentiation
regulation of branch elongation involved in ureteric bud branching
mesonephric duct formation
negative regulation of mesenchymal cell apoptotic process involved in metanephros development
