Active Motif

Histone H3K9me1me2 Recombinant Rabbit Monoclonal Antibody (1E12)

Name: Histone H3K9me1me2 Recombinant Rabbit Monoclonal Antibody (1E12)
Brand: Active Motif
SKU: 91651ACTMOTIF
Availability: InStock

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

产品信息

91651ACTMOTIF

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:50,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

1E12

抗原

This information is proprietary to Active Motif and/or its suppliers.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Histone modifications like H3K9me1 and H3K9me2 play crucial roles in the regulation of gene expression and chromatin structure. Monomethylation (H3K9me1) is often linked to active transcription, whereas dimethylation (H3K9me2) is generally associated with gene silencing and the formation of heterochromatin, a transcriptionally inactive structure. The enzyme G9a and its partner GLP are primarily responsible for catalyzing H3K9me2, which is critical for the balance between different chromatin states and the maintenance of genomic compartments. Studies have highlighted that H3K9me2 is vital for the repression of transcription in certain genomic regions, producing distinct epigenetic landscapes necessary for cellular function and identity. Furthermore, specific small molecules, such as BIX-01294, have been developed as inhibitors to modulate the levels of H3K9me2, underscoring its reversible nature and therapeutic potential in diseases characterized by epigenetic dysregulation. Such methylation marks are dynamically regulated across cell cycle phases and play distinct roles depending on the genomic context, further illustrating their complexity in gene regulatory networks.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; H3-clustered histone 2; H3-clustered histone 3; H3-clustered histone 4; H3-clustered histone 6; H3-clustered histone 7; histone 1, H2ai; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3c2; histone 2, H3ca2; histone cluster 1, H2ai; histone cluster 1, H2ai-like; histone cluster 1, H3a; histone cluster 2, H3c2; histone cluster 2, H3c2, pseudogene; histone cluster 3, H3; histone gene complex 1; histone H3; Histone H3.1; Histone H3.2; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; Histone H3/m; Histone H3/o; Histone H3K9me1me2

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基因别名: H3 histone; H3-143; H3-291; H3-53; H3-614; H3-B; H3-F; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3a; H3b; H3C1; H3C10; H3C11; H3C12; H3C13; H3C14; H3C15; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3f; H3F2; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3g; H3h; H3i; Hist1; Hist1h2ai; Hist1h2ail; HIST1H3A; HIST1H3B; Hist1h3c; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST2H3A; Hist2h3b; HIST2H3C; Hist2h3c1; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1; Hist2h3ca2; HIST2H3D; M32461