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PA5-19475 targets Histone H4 in Western blot and flow cytometry applications and shows reactivity with Bovine, Human, and Yeast samples.
The PA5-19475 immunogen is recombinant full length protein of Saccharomyces cerevisiae Histone H4 expressed in E. coli.
PA5-19475 detects Histone H4 which has a predicted molecular weight of approximately 14 kDa.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。