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Invitrogen
IBA1 Monoclonal Antibody (1022-5)
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产品信息
MA1-40227
应用
建议稀释比
已发表文章
产品规格
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1022-5
抗原
Recombinant human AIF-1
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-40227 detects AIF1 from human and rat samples.
MA1-40227 has been successfully used in ELISA, immunohistochemistry (paraffin) and Western blot applications.
The MA1-40227 immunogen is human AIF1 polypeptide.
靶标信息
Ionized calcium-binding adapter molecule 1 (IBA1), also known by its gene name AIF1, is a protein expressed predominantly by microglia in the brain and spinal cord. This protein belongs to the EF-hand calcium-binding protein family and plays a crucial role in microglial activation and migration in response to brain injury or neuroinflammation. IBA1's function is integral to microglial motility and phagocytic activity, facilitating the cellular response to pathogenic stimuli and promoting tissue homeostasis and repair in the central nervous system. IBA1 serves as a reliable marker for activated microglia in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where increased expression correlates with disease progression and severity. The protein's structural features enable it to bind calcium ions, inducing conformational changes that activate signaling pathways essential for microglial function. Its expression is highly regulated by inflammatory cytokines, underpinning its role in neuroimmune responses. Due to its specific expression in microglia during pathological conditions, IBA1 is widely used in research as a marker to study microglial status and activity, and it remains a focal point for understanding microglial involvement in neurodegenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
