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Invitrogen
IFIT1 Polyclonal Antibody
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IFIT1 Antibody (PA3-846) in WB
mBio 2018 -
FIG 5 Reduced temperature also affects IFN-alpha/beta induction. (A to C) MEFs were transfected with 50 µg poly(I:C) per million cells using electroporation. Pooled transfections were then divided among 30, 37, and 39degC temperature conditions. (A) Supernatants were assayed for biologically active IFN-alpha/beta as described in Materials and Methods. Data are presented as log 10 mean IU per milliliter +- S... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA3-846
应用
建议稀释比
已发表文章
产品规格
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
aa 217-233 of mouse IFIT1
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA3-846 detects ISG56 (p56) from mouse samples.
PA3-846 has been successfully used in Western blot applications to detect a 39-58 kDa band.
靶标信息
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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