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Proteintech
IGF2BP3 Polyclonal Antibody
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产品信息
14642-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
IGF2BP3 Fusion Protein Ag6226 (240-579 aa encoded by BC065269)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Both isoforms (64 kDa and 22 kDa) of IGFBP3 can be recognized by this antibody. IGFBP3 is nuclear and cytoplasmic in staining.
Immunogen sequence: AEKSITILS TPEGTSAACK SILEIMHKEA QDIKFTEEIP LKILAHNNFV GRLIGKEGRN LKKIEQDTDT KITISPLQEL TLYNPERTIT VKGNVETCAK AEEEIMKKIR ESYENDIASM NLQAHLIPGL NLNALGLFPP TSGMPPPTSG PPSAMTPPYP QFEQSETETV HLFIPALSVG AIIGKQGQHI KQLSRFAGAS IKIAPAEAPD AKVRMVIITG PPEAQFKAQG RIYGKIKEEN FVSPKEEVKL EAHIRVPSFA AGRVIGKGGK TVNELQNLSS AEVVVPRDQT PDENDQVVVK ITGHFYACQV AQRKIQEILT QVKQHQQQKA LQSGPPQSRR K (240-579 aa encoded by BC065269)
靶标信息
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cancer/testis antigen 98; hKOC; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; insulin-l; insulin-like growth factor 2 mRNA binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2, binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; mIMP-3; VICKZ family member 3
基因别名: 2610101N11Rik; AA522010; AL022933; AU045931; CT98; IGF2BP3; IMP-3; IMP3; KOC; KOC1; Koc13; mimp3; Neilsen; VICKZ3
UniProt ID: (Human) O00425, (Mouse) Q9CPN8
Entrez Gene ID: (Human) 10643, (Mouse) 140488
