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Proteintech
IL-23R Polyclonal Antibody
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产品信息
31798-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
550 µg/mL
规格
82.5 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Sequence of this protein is as follows: GITNINCSGH IWVEPATIFK MGMNISIYCQ AAIKNCQPRK LHFYKNGIKE RFQITRINKT TARLWYKNFL EPHASMYCTA ECPKHFQETL ICGKDISSGY PPDIPDEVTC VIYEYSGNMT CTWNAGKLTY IDTKYVVHVK SLETEEEQQY LTSSYINIST DSLQGGKKYL VWVQAANALG MEESKQLQIH LDDIVIPSAA VISRAETINA TVPKTIIYWD SQTTIEKVSC EMRYKATTNQ TWNVKEFDTN FTYVQQSEFY LEPNIKYVFQ VRCQETGKRY WQPWSSLFFH KTPETVPQVT SKAFQHDTWN SGLTVASIST GHLTSDNRGD IG
靶标信息
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hemopoietic cytokine receptor; IBD17; IL 23R; IL-23 receptor; IL-23R endodomain protein; IL-23R3-F3; IL-23R soluble receptor; IL-23R2-F1; IL-23R soluble receptor; IL-23R3-F1; IL-23R soluble receptor; IL-23R4; IL-23R truncated endodomain protein; IL-23R2-F2; Interleukin-23 receptor; type I cytokine receptor; IL-23R1
基因别名: IL23R; PSORS7
UniProt ID: (Human) Q5VWK5
Entrez Gene ID: (Human) 149233
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
immune system process
positive regulation of T-helper 1 type immune response
inflammatory response
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
response to interferon-gamma
interleukin-23-mediated signaling pathway
prolactin signaling pathway
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
innate immune response
positive regulation of osteoclast differentiation
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
receptor signaling pathway via STAT
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
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