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Invitrogen
IL-32 Recombinant Rabbit Monoclonal Antibody (IL-32-Clone 281)
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IL-32 Antibody (704980) in WB
Western blot (Fig. a) was performed using IL-32 Recombinant Rabbit Monoclonal Antibody (IL-32-Clone 281) (Product # 704980) and a ~25 kDa band corresponding to IL-32 was observed upon treatment of A549 and HT-29 with Rec. Human TNF alpha and PTI; shorter isoform at ~12 kDa was detected in Jurkat treated with PTI. Whole cell extracts treated with PTI (1X for 4 hrs) (30 µg lysate) of Jurkat (Lane 1), A549 (Lane 2), A549 treated with Rec. Human TNF alpha (25 ng/mL for 24 hrs) (Lane 3), HT-29 (Lane 4), HT-29 treated with Rec. Human TNF alpha (... View More
产品信息
704980
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
IL-32-Clone 281
抗原
Protein corresponding to human IL-32 [aa1-aa131]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant Rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
Interleukin-32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32. IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Because treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-a, IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFN-gamma, it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytokine; IL-32; IL-32s; ILN; inflammatory cytokine; Interleukin; Interleukin-32; interleukin-32 eta; interleukin-32 small; interleukin-32 theta; natural killer cell transcript 4; Natural killer cells protein 4; putative; Tumor necrosis factor alpha-inducing factor; unnamed protein product
基因别名: IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; IL32; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd
UniProt ID: (Human) P24001
Entrez Gene ID: (Human) 9235
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