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Despite its predicted molecular weight, IL-34 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is human brain tissue lysate.
PA5-20585 can be used with blocking peptide PEP-0705.
IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: IL-34; ILN; Interleukin; Interleukin-34; Interleukin34
基因别名: 2010004A03Rik; AI593503; C16orf77; IL-34; IL34
UniProt ID: (Human) Q6ZMJ4, (Mouse) Q8R1R4, (Rat) Q4KM46
Entrez Gene ID: (Human) 146433, (Mouse) 76527, (Rat) 498951