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Abnova
IL12RB2 Monoclonal Antibody (2H6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00003595-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2H6
抗原
IL12RB2 (NP_001550, 105 a.a. approximately 214 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: CINSDEIQIC GAEIFVGVAP EQPQNLSCIQ KGEQGTVACT WERGRDTHLY TEYTLQLSGP KNLTWQKQCK DIYCDYLDFG INLTPESPES NFTAKVTAVN SLGSSSSLPS
靶标信息
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; RP11-102M16.1; unnamed protein product
UniProt ID: (Human) Q99665
Entrez Gene ID: (Human) 3595
negative regulation of T-helper 1 type immune response
immune response
cell surface receptor signaling pathway
positive regulation of cell proliferation
cytokine-mediated signaling pathway
regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of natural killer cell proliferation
response to cytokine
interleukin-12-mediated signaling pathway
positive regulation of T cell proliferation
positive regulation of JAK-STAT cascade
positive regulation of NK T cell proliferation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
