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Invitrogen
IL1RAPL1 Polyclonal Antibody
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IL1RAPL1 Antibody (PA5-96244) in WB
Western blot analysis of IL1RAPL1 in extracts of various cell lines. Samples were incubated with IL1RAPL1 Polyclonal antibody (Product # PA5-96244) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-96244
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human IL1RAPL1 (NP_0550861)
偶联物
形式
Liquid
浓度
3.07 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SISLTVGEND TGLCYNSKMK YFEKAELSKS KEISCRDIED FLLPTREPEI LWYKECRTKT WRPSIVFKRD TLLIREVRED D; Positive Samples: A-431, Mouse brain, Mouse heart, Rat brain, Rat heart; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Single-pass type I membrane protein, axon, dendrite
靶标信息
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signaling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; Interleukin-1 receptor accessory protein-like 1; mental retardation, X-linked 10; Oligophrenin-4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
基因别名: 6330532G10Rik; C030039N24; IL1R8; IL1RAPL; IL1RAPL1; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2
UniProt ID: (Human) Q9NZN1, (Rat) P59824
Entrez Gene ID: (Human) 11141, (Mouse) 331461, (Rat) 317553
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
regulation of neuron projection development
neuron differentiation
negative regulation of exocytosis
positive regulation of dendrite morphogenesis
calcium ion transmembrane transport
presynaptic membrane assembly
regulation of ion transmembrane transport
