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0.25 mg/ml was sufficient for detection of PA5-77823 in lysates prepared from human melanoma cell lines by western blot analysis.|Detects approximately 33kDa.
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
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