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Proteintech
INO80 Monoclonal Antibody (1F11C5), CoraLite® Plus 488
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产品信息
CL488-68064
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1F11C5
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: KQVTVYRLIC KGTIEERILQ RAKEKSEIQR MVISGGNFKP DTLKPKEVVS LLLDDEELEK KLRLRQEEKR QQEETNRVKE RKRKREKYAE KKKKEDELDG KRRKEGVNLV IPFVPSADNS NLSADGDDSF ISVDSAMPSP FSEISISSEL HTGSIPLDES SSDMLVIVDD PASSAPQSRA TNSPASITGS VSDTVNGISI QEMPAAGRGH SARSRGRPKG SGSTAKGAGK GRSRKSTAGS AAAMAGAKAG AAAASAAAYA AYGYNVSKGI SASSPLQTSL VRPAGLADFG PSSASSPLSS PLSKGNNVPG NPKNLHMTSS LAPDSLVRKQ GKGTNPSGGR
靶标信息
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chromatin-remodeling ATPase INO80; DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; INO80 complex homolog 1; INO80 complex subunit A; INO80 homolog; putative DNA helicase INO80 complex homolog 1; yeast INO80-like protein
基因别名: 2310079N15Rik; 4632409L19Rik; hINO80; INO80; INO80A; INOC1; KIAA1259; RGD1310969
UniProt ID: (Human) Q9ULG1, (Mouse) Q6ZPV2
Entrez Gene ID: (Human) 54617, (Mouse) 68142, (Rat) 296084
mitotic sister chromatid segregation
double-strand break repair via homologous recombination
DNA repair
double-strand break repair
DNA recombination
chromatin remodeling
cellular response to DNA damage stimulus
cell cycle
mitotic nuclear division
positive regulation of nuclear cell cycle DNA replication
positive regulation of cell growth
DNA duplex unwinding
cellular response to UV
positive regulation of transcription from RNA polymerase II promoter
spindle assembly
cell division
UV-damage excision repair
cellular response to ionizing radiation
regulation of G1/S transition of mitotic cell cycle
transcription, DNA-templated
biological_process
metabolic process
