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Proteintech
INPPL1 Polyclonal Antibody
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产品信息
26678-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
INPPL1 fusion protein Ag24790
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: DGEDFLAVQT SQGVPVRRFQ TLGELIGLYA QPNQGLVCAL LLPVEGEREP DPPDDRDASD GEDEKPPLPP RSGSTSISAP TGPSSPLPAP ETPTAPAAES APNGLSTVSH DYLKGSYGLD LEAVRGGASH LPHLTRTLAT SCRRLHSEVD KVLSGLEILS KVFDQQSSPM VTRLLQQQNL PQTGEQELES LVLKLSVLKD FLSGIQKKAL KALQDMSSTA PPAPQPSTRK AKTIPVQAFE VKLDVTLGDL TKIGKSQKFT LSVDVEGGRL VLLRRQRDSQ EDWTTFTHDR IRQ
靶标信息
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodeling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 51C protein; ablSH3-binding protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2
基因别名: 51C; INPPL1; OPSMD; SHIP2
UniProt ID: (Human) O15357, (Mouse) Q6P549
Entrez Gene ID: (Human) 3636, (Mouse) 16332
actin binding
protein binding
SH3 domain binding
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
SH2 domain binding
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate binding
hydrolase activity
endochondral ossification
immune system process
glucose metabolic process
phosphatidylinositol biosynthetic process
endocytosis
actin filament organization
cell adhesion
negative regulation of cell proliferation
post-embryonic development
negative regulation of gene expression
response to insulin
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
ruffle assembly
negative regulation of DNA replication
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of neuron projection development
dephosphorylation
inositol trisphosphate metabolic process
negative regulation of MAP kinase activity
negative regulation of insulin-like growth factor receptor signaling pathway
cellular lipid metabolic process
negative regulation of insulin receptor signaling pathway
