Proteintech

INSR Polyclonal Antibody

23 篇参考文献

查看其他29个INSR抗体

问题与答案

问题与答案

问题与答案

抗体检测数据 (6)

INSR Antibody in Western Blot (WB)

INSR Antibody in Western Blot (WB)

图: 1 / 6

INSR Antibody (20433-1-AP) in WB

HT-1080 cells were subjected to SDS PAGE followed by western blot with 20433-1-AP (INSR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

INSR Antibody in Western Blot (WB)

INSR Antibody in Western Blot (WB)

INSR Antibody in Western Blot (WB)

INSR Antibody in Western Blot (WB)

INSR Antibody in Western Blot (WB)

INSR Antibody in Immunoprecipitation (IP)

Product Image Gallery

INSR Antibody in Western Blot (WB) — HT-1080 cells were subjected to SDS PAGE followed by western blot with 20433-1-AP (INSR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

INSR Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 20433-1-AP (INSR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

INSR Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 20433-1-AP (INSR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

INSR Antibody in Western Blot (WB) — MCF7 cells were subjected to SDS PAGE followed by western blot with 20433-1-AP (INSR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

INSR Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 20433-1-AP (INSR antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours.

INSR Antibody in Immunoprecipitation (IP) — IP result of anti-INSR (IP:20433-1-AP, 4ug; Detection:20433-1-AP 1:500) with HeLa cells lysate 1600ug.

Immunogen image

INSR Polyclonal Antibody

Immunogen Image INSR Polyclonal Antibody

产品信息

20433-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

Assay-dependent

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免疫沉淀 (IP)

0.5-4.0 µg

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点杂交 (DB)

-

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产品规格

种属反应

Human

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

INSR Fusion Protein Ag13922 (980-1382 aa encoded by BC117172)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: RKRQPDGPL GPLYASSNPE YLSASDVFPC SVYVPDEWEV SREKITLLRE LGQGSFGMVY EGNARDIIKG EAETRVAVKT VNESASLRER IEFLNEASVM KGFTCHHVVR LLGVVSKGQP TLVVMELMAH GDLKSYLRSL RPEAENNPGR PPPTLQEMIQ MAAEIADGMA YLNAKKFVHR DLAARNCMVA HDFTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMAPESL KDGVFTTSSD MWSFGVVLWE ITSLAEQPYQ GLSNEQVLKF VMDGGYLDQP DNCPERVTDL MRMCWQFNPK MRPTFLEIVN LLKDDLHPSF PEVSFFHSEE NKAPESEELE MEFEDMENVP LDRSSHCQRE EAGGRDGGSS LGFKRSYEEH IPYTHMNGGK KNGRILTLPR SNPS (980-1382 aa encoded by BC117172)

靶标信息

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CD 220; CD220; CD220 antigen; CD220 beta; CD221; HHF 5; IGF-I receptor; Insulin receptor; IR; IR 1; IR beta; IR-1; IR1

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基因别名: CD220; HHF5; INSR

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UniProt ID: (Human) P06213

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Entrez Gene ID: (Human) 3643

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protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding protein binding ATP binding GTP binding protein phosphatase binding lipoic acid binding insulin-like growth factor I binding insulin-like growth factor II binding protein complex binding 3-phosphoinositide-dependent protein kinase binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding PTB domain binding transmembrane signal receptor

activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation heart morphogenesis carbohydrate metabolic process regulation of transcription, DNA-templated G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway epidermis development male gonad development response to manganese ion regulation of hydrogen peroxide metabolic process positive regulation of glycoprotein biosynthetic process negative regulation of gene expression response to activity peptidyl-tyrosine phosphorylation transformation of host cell by virus signal transduction by protein phosphorylation male sex determination adrenal gland development positive regulation of cell migration exocrine pancreas development activation of protein kinase activity activation of protein kinase B activity response to estradiol negative regulation of transporter activity cellular response to insulin stimulus response to vitamin D response to testosterone response to tumor necrosis factor peptidyl-tyrosine autophosphorylation glucose homeostasis positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process fat cell differentiation response to ethanol positive regulation of glycogen biosynthetic process positive regulation of DNA replication positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import protein autophosphorylation positive regulation of developmental growth protein heterotetramerization response to glucocorticoid positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling positive regulation of respiratory burst cellular response to growth factor stimulus regulation of female gonad development