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Invitrogen
IO-108 Recombinant Human Monoclonal Antibody
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产品信息
MA562632
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.65 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
IO-108 is a monoclonal antibody biosimilar developed to target the LILRB2 receptor also known as ILT4 which plays a central role in immune suppression by binding to HLA-G and other ligands. This receptor is expressed on myeloid cells and contributes to the immune system's regulatory processes often co-opted by cancer cells to evade immune detection. IO-108 is designed to inhibit the interaction between ILT4 and its ligands thereby enhancing immune cell activation and promoting anti-tumor responses. As an IgG1 antibody it is formulated for research purposes to explore its efficacy in disrupting immunosuppressive pathways. Preclinical and clinical studies aim to elucidate its therapeutic potential especially in combination with other immunotherapies such as checkpoint inhibitors to enhance cancer treatment efficacy by restoring immune surveillance capabilities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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