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Invitrogen
IRAK1 Polyclonal Antibody
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IRAK1 Antibody (PA5-85308) in WB
Western blot was performed using Anti-IRAK1 Polyclonal Antibody (Product # PA5-85308) and a 80kDa band corresponding to Interleukin-1 receptor-associated kinase 1 was observed across tested cell lines with uncharacterized bands (*) at ~110 and 160 kDa. Whole cell extracts (40 µg lysate) of THP-1 (Lane 1), Jurkat (Lane 2), K-562 (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting Syste... View More
产品信息
PA5-85308
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human IRAK1.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (90%), Rat (92%), Bovine (89%).
Positive Control: HepG2, PC-12, Rat-2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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