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Proteintech
IRG1 Polyclonal Antibody
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产品信息
28436-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: DAAASVRKHL VAERALLPTD YIKRIVLRIP NVQYVNRPFP VSEHEARHSF QYVACAMLLD GGITVPSFHE CQINRPQVRE LLSKVELEYP PDNLPSFNIL YCEISVTLKD GATFTDRSDT FYGHWRKPLS QEDLEEKFRA NASKMLSWDT VESLIKIVKN LEDLEDCSVL TTLLKGPSPP EVASNSPACN NSITNLS
靶标信息
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aconitate decarboxylase; Aconitate decarboxylase 1; CAD; Cis-aconitate decarboxylase; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein; immune-responsive gene 1 protein homolog; immunoresponsive 1 homolog
基因别名: ACOD1; AI323667; CAD; IRG1
UniProt ID: (Human) A6NK06, (Mouse) P54987
Entrez Gene ID: (Human) 730249, (Mouse) 16365
positive regulation of antimicrobial humoral response
defense response
inflammatory response
embryo implantation
metabolic process
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
cellular response to interferon-beta
negative regulation of innate immune response
negative regulation of inflammatory response
cellular response to molecule of bacterial origin
cellular response to lipopolysaccharide
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to progesterone stimulus
tolerance induction to lipopolysaccharide
positive regulation of reactive oxygen species metabolic process
immune system process
propionate catabolic process
response to lipopolysaccharide
innate immune response
