MUbio

Integrin alpha 3B,alpha 6B Monoclonal Antibody (PB36)

Name: Integrin alpha 3B,alpha 6B Monoclonal Antibody (PB36)
Brand: MUbio
SKU: MUB0903P

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

MUB0903P

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:100-1:500

免疫组化（冰冻） (IHC (F))

1:50-1:100

免疫细胞化学 (ICC/IF)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

PB36

抗原

Integrin alpha 3B + alpha 6B

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

PB36 recognizes the cytoplasmic domain of integrin subunits alpha-3B and alpha-6B. PB36 reacts with the basement membrane zone and endothelial cells in skin, tubuli in kidney and all vascular and capillary endothelia in brain and heart.

A broad species reactivity is expected because of the conserved nature of the epitope.

The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.

靶标信息

Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha-3 and alpha-6, two cytoplasmic variants, A and B, have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: alpha 3 subunit of VLA-3 receptor; antigen CD49C; antigen identified by monoclonal antibody J143; CD49 antigen-like family member C; CD49 antigen-like family member F; CD49c; CD49f; FRP-2; Galactoprotein B3; GAPB3; integrin alpha 3; integrin alpha 6; Integrin alpha-3; Integrin alpha-6; integrin alpha6B; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); integrin, alpha 6; testicular tissue protein Li 96; testicular tissue protein Li 98; very late activation protein 3 receptor, alpha-3 subunit; VLA-3 subunit alpha; VLA-6

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基因别名: CD49C; CD49f; FRP-2; GAP-B3; GAPB3; ILNEB; ITGA3; ITGA6; ITGA6B; MSK18; VCA-2; VL3A; VLA-6; VLA3a

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UniProt ID: (Human) P26006, (Human) P23229

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Entrez Gene ID: (Human) 3675, (Human) 3655

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