Search
Fabgennix
JMJD2D Polyclonal Antibody, FITC
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
JUMD-FITC
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 340-390 on human Jumonji domain containg 2D protein.
偶联物
FITC
FITC
FITC
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
保存条件
-20°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The JMJD2D gene encodes a member of the Jumonji C domain-containing histone demethylases, which are involved in the epigenetic regulation of gene expression by demethylating lysine residues on histone proteins. JMJD2D specifically interacts with β-catenin and is implicated in colorectal cancer, where it activates transcription of target genes and promotes cell proliferation, migration, and tumor formation. Structurally, JMJD2D belongs to the JMJD2 family but exhibits distinct features, lacking certain regions that make it the most structurally divergent within the family. Additionally, JMJD2D stabilizes and cooperates with the hepatitis B virus protein HBx, facilitating cccDNA transcription by demethylating H3K9me3 and counteracting the repressive effects of p53. JMJD2D's role in various cellular processes highlights its importance in both cancer pathogenesis and viral replication, making it a potential target in therapeutic research for colorectal cancer and hepatitis B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
