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Proteintech
JUN Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
24909-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Hamster,
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
JUN Fusion Protein Ag17639 (92-227 aa encoded by BC068522)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.73 mg/mL
规格
109.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is a rabbit polyclonal antibody raised against a region of human JUN. Both phosphorylated (p-c-Jun) and unphosphorylated forms of c-Jun, with sizes of 42-45 kDa and 36-39 kDa, respectively are obtain in some experiments.
Immunogen sequence: PTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKE (92-227 aa encoded by BC068522)
靶标信息
c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activator protein 1; AH119; AP1; c-jun protein; cjun; enhancer-binding protein AP1; immediate early; JUN; jun A; Jun activation domain binding protein; Jun oncogene; jun proto-oncogene; JUND; proto-oncogene c-Jun; proto-oncogene cJun; Transcription factor AP-1; transcription factor AP-1 subunit Jun; unnamed protein product; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
基因别名: AP-1; AP1; c-Jun; cJUN; I79_009953; Junc; p39
UniProt ID: (Human) P05412, (Mouse) P05627
Entrez Gene ID: (Human) 3725, (Mouse) 16476, (Chinese hamster) 100766306
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
RNA binding
GTPase activator activity
protein binding
enzyme binding
ubiquitin protein ligase binding
cAMP response element binding
identical protein binding
ubiquitin-like protein ligase binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
R-SMAD binding
general transcription initiation factor binding
sequence-specific double-stranded DNA binding
sequence-specific DNA binding
macromolecular complex binding
HMG box domain binding
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
JNK cascade
release from viral latency
transforming growth factor beta1 production
response to endoplasmic reticulum stress
regulation of cell proliferation
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to steroid hormone
regulation of cell cycle
SMAD protein signal transduction
cellular response to anisomycin
integrated stress response signaling
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of vascular smooth muscle cell proliferation
positive regulation of DNA-templated transcription, initiation
angiogenesis
microglial cell activation
release of cytochrome c from mitochondria
liver development
positive regulation of endothelial cell proliferation
outflow tract morphogenesis
transcription, DNA-templated
transcription from RNA polymerase II promoter
learning
circadian rhythm
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
response to mechanical stimulus
positive regulation of epithelial cell migration
monocyte differentiation
axon regeneration
negative regulation of protein autophosphorylation
response to lipopolysaccharide
response to insulin
response to cytokine
cellular response to zinc ion starvation
leading edge cell differentiation
response to muscle stretch
response to hydrogen peroxide
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
response to ethanol
positive regulation of monocyte differentiation
positive regulation of DNA replication
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
cellular response to potassium ion starvation
response to cAMP
membrane depolarization
eyelid development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
cellular response to calcium ion
cellular response to hypoxia
response to forskolin
cellular response to prolactin
positive regulation of apoptotic signaling pathway
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